Publications
A collection of our scientific contributions to the fields of bioinformatics, molecular modeling, and antimicrobial resistance, reflecting our commitment to advancing global health through computational research.
2026
Springer Nature
Genomics of Hospital-Associated Brazilian Multidrug-Resistant Klebsiella pneumoniae: Abundance of Resistance and Virulence Genes and Mosaicism of the blaKPC−2 Genetic Context Among Enterobacterales
ACS Omega
Structure-Based Strategy Reveals a Novel Ligand Binding Site in Staphylococcus aureus Catabolite Control Protein A: Implications for Transcriptional Regulation and Drug Design
mSystems
Empowering global disease surveillance with CURED: a tool for rapid identification of unique genomic biomarkers
Ambio
Wildfire smoke and antimicrobial resistance: A hidden link demanding global attention
International Journal of Antimicrobial Agents
Corrigendum to "Phage therapy for KPC-producing Klebsiella pneumoniae decolonization in high-risk patients: The KIDNAP Study Protocol"
The Lancet Regional Health – Americas
Daily Chlorhexidine Bathing for the Prevention of Nosocomial Infections in Critically Ill Patients (CLEAN-IT)
npj Antimicrobials and Resistance
Artificial intelligence for early detection and risk prediction of antimicrobial resistance in aquatic ecosystems
The Brazilian Journal of Infectious Diseases
Implementation of a Bundle of Measures to Prevent the Dissemination of Resistant Microorganisms in Two Brazilian Public Hospitals
The Brazilian Journal of Infectious Diseases
Antimicrobial Resistance Genes in Enterococcus spp. in Brazil: Clinical, Food, Environmental, and Animal Evidence
The Brazilian Journal of Infectious Diseases
Phenotypic and Genotypic Characterization of Carbapenem-Resistant Klebsiella pneumoniae Isolated in a State of the Brazilian Amazon
The Brazilian Journal of Infectious Diseases
Genomic Analysis of Pseudomonas aeruginosa Carrying blaGES-1 and blaKPC-2 Isolated from Bloodstream Infection in Rondônia
Microbiology Spectrum
Synergistic effects of ceftriaxone combined with BLI-489 against NDM-producing Klebsiella pneumoniae
JAC-Antimicrobial Resistance
Management of metallo-β-lactamase-producing Enterobacterales infections: a modified Delphi study
ChemRxiv (Preprint)
Structure-based strategy reveals a novel ligand binding site in Staphylococcus aureus catabolite control protein A: implications for transcriptional regulation and drug design
ACS Omega
Machine Learning and Molecular Modeling for Drug Repurposing Targeting Potential PI3Kα Inhibitors in Post-CoViD-19 Pulmonary Fibrosis
eLife
Single-cell RNA-seq reveals trans-sialidase-like superfamily gene expression heterogeneity in Trypanosoma cruzi populations
Pharmaceuticals
Phosphatidylinositol-3-Kinase (PI3K) and Histone Deacetylase (HDAC) Multitarget Inhibitors: An Update on Clinical and Preclinical Candidates
Frontiers in Microbiology
Description and complete genome sequence of Mycobacterium venezuelense sp. nov., a rapidly growing species recovered from a soft tissue infection
Molecular Ecology
Genetic Diversity of Polymyxin Resistance Genes in Klebsiella pneumoniae Clinical Isolates
International Journal of Antimicrobial Agents
In Reply to the Letter to Editor Regarding "Phage Therapy for KPC-Producing Klebsiella pneumoniae Decolonization in High-Risk Patients: The KIDNAP Study Protocol - A Prospective Feasibility and Proof of Concept Study in the Brazilian Context"
The Brazilian Journal of Infectious Diseases
Impact of Antimicrobial Use on Resistance in Gram-Negative Bacilli: A Secondary Analysis of ANVISA Data (2019–2023)
The Brazilian Journal of Infectious Diseases
Laboratory-Confirmed Central Venous Catheter–Associated Bloodstream Infections in Intensive Care Units in Brazil: Ecological Study with ANVISA Data 2019–2023
Open Forum Infectious Diseases
Optimizing Management of Infections Caused by Metallo-β-Lactamase (MBL)–Producing Enterobacterales: An International Modified Delphi Study
International Journal of Molecular Sciences
LASSBio-1986 as a Multifunctional Antidiabetic Lead: SGLT1/2 Docking, Redox-Inflammatory Modulation and Metabolic Benefits in C57BL/6 Mice
Journal of Chromatography B
Bioanalytical HPLC–DAD method for determining (E)-1-4(trifluoromethyl) benzylidene)-5-(2-4-dichlorozoyl) carbonylhydrazine (LASSBio-1736), a promising antileishmanial compound in canine plasma applied to pharmacokinetic studies
ACS Omega
Big Data for Drug Discovery: Some Historical Landscape, Considerations, and Applications for a Medicinal Chemist
ACS Omega
New Dual Pan-PI3K/mTOR Inhibitor: Design, Synthesis, Cytotoxic Action, Permeation, Metabolic Stability, and In Silico Protein-Ligand Interaction
Memórias do Instituto Oswaldo Cruz
Transcriptomic dynamics reveals sequential acquisition of complement resistance during prolonged starvation of Trypanosoma cruzi epimastigote
PLoS One
Beyond the transcript: Chromatin implications in trans-splicing in Trypanosomatids
Antibiotics
Oxidative Stress Reshapes Porphyromonas gingivalis Outer Membrane Vesicles and Impairs OMV-Mediated Invasion and Persistence in Trophoblast Cells
Revista Argentina de Microbiología
Predictors of rectal carriage of carbapenemase-producing Gram-negative bacteria in general wards: A case–control study
npj Antimicrobials and Resistance
Global perspectives on Klebsiella epidemiology and biology: conference report on the KLEBS 2024 symposium
2025
BMC Infectious Diseases
Genomic characterization of XDR Mycobacterium tuberculosis isolates in Argentina (2006–2015)
bioRxiv (Preprint)
Transcriptional Profiling and Co-expression Integration for the Filtering of Relevant Bacterial sRNA–mRNA Interactions: Application to Staphylococcus aureus Biofilm
Journal of Medical Microbiology
Matrix-assisted laser desorption/ionization-time of flight MS as a tool for clonal discrimination in Streptococcus dysgalactiae subsp. equisimilis
Frontiers in Microbiology
Decoding the evolutionary history of ST30 Staphylococcus aureus: insights into a potentially silent MSSA bloodstream pathogen
Clinical Microbiology Reviews
Current and future options for the treatment of serious infections due to carbapenem-resistant Pseudomonas aeruginosa
Antimicrobial Agents and Chemotherapy
ISAba1-mediated blaADC disruption restores third-generation cephalosporin susceptibility in a clinical Acinetobacter baumannii isolate
CMI Communications
Phage research in South America: A descriptive overview of trends and gaps
International Journal of Antimicrobial Agents
Phage therapy for KPC-producing Klebsiella pneumoniae decolonization in high-risk patients: The KIDNAP Study Protocol
The Brazilian Journal of Infectious Diseases
Guideline for antimicrobial treatment of multidrug-resistant Gram-negative infections: practice recommendations of the Brazilian Society of Infectious Diseases
Anthropocene Science
Impact of Climate Change-Mediated Tragedies: An Account of Extreme Rainfall Event in Rio Grande do Sul, Brazil
Expert Opinion on Therapeutic Patents
The potential of bacteriophages in treating multidrug-resistant ESKAPE pathogen infections
Clinical Microbiology and Infection
How do I manage difficult-to-treat Pseudomonas aeruginosa infections?: Key questions for today's clinicians
One Health
Phylogenomic analysis of aquatic and clinical OXA-23-positive Acinetobacter baumannii belonging to the international clone 5 (ST79) from Southeast Brazil
Journal of Global Antimicrobial Resistance
Salmonella Minnesota sequence type 548 harboring a type 2 IncC megaplasmid of antimicrobial resistance and virulence infecting a companion animal
JAC-Antimicrobial Resistance
The impact of the COVID-19 pandemic on antimicrobial usage: an international patient-level cohort study
The Brazilian Journal of Infectious Diseases
Experience in Ceftazidime-Avibactam for treatment of MDR BGN infection in Oncologic Children
Database
ENcyclopedia of TRAnscription Factors in Bacteria and Archaea genomes (ENTRAF) version 2.0
Scientific Reports
In vitro assays identified thiohydantoins with anti-trypanosomatid activity and molecular modelling studies indicated possible selective CYP51 inhibition
Scientific Reports
In silico evaluation of N-aryl-1,10-phenanthroline-2-amines as potential inhibitors of T. cruzi GP63 zinc-metalloprotease
Current Medicinal Chemistry
Natural and Synthetic Coumarins as Potential Drug Candidates against SARS-CoV-2/COVID-19
ACS Omega
Molecular Dynamics Studies on Trypanosoma cruzi Dihydroorotate Dehydrogenase Complexes: An Analysis of the Inhibitor Influence
Journal of Natural Pesticide Research
Larvicidal effects of Myrciaria floribunda nanoemulsion against Aedes aegypti
Frontiers in Microbiology
Phylogenomic insights into LA-MRSA from Argentine pig farm environments: novel OptrA variant and regional emergence of an ST9 lineage
Environmental Microbiology Reports
Genomic Analysis and Virulence Features of Vibrio cholerae Non-O1/Non-O139 Harbouring CARB-Type β-Lactamases
Microbial Pathogenesis
Genome characterization of Enterococcus lactis strain isolated from bovine subclinical mastitis
PLoS Pathogens
Expanding kinetoplastid genome annotation through protein structure comparison
Bacterial Enzymes as Targets for Drug Discovery
Computational tools to identify potential drug targets in bacteria
Science of the Total Environment
Co-occurrence of SARS-CoV-2 variants in rivers and sewage in India and Brazil
Microbial Ecology
Genomic Repertoire of Twenty-Two Novel Vibrionaceae Species Isolated from Marine Sediments
Pharmaceuticals
Novel Multifunctional Cannabidiol-Based Analogues with In Silico, In Vitro, and In Vivo Anti-SARS-CoV-2 Effect
ChemRxiv (Preprint)
Data-centric training enables meaningful interaction learning in protein–ligand binding affinity prediction
Bioorganic Chemistry
The discovery of a new uncompetitive inhibitor of nucleoside hydrolase from Leishmania donovani
Pharmaceuticals
Drug Discovery for Histone Deacetylase Inhibition: Past, Present and Future of Zinc-Binding Groups
European Journal of Medicinal Chemistry
Design, synthesis and pharmacological evaluation of multitarget GPR40 agonists/HDAC6 inhibitors for Alzheimer's disease
ACS Infectious Diseases
Collaborative Synthesis for Neglected Diseases through the Open Synthesis Network: Arylaminopyrazoles as Chagas Disease Treatments
ACS Pharmacology & Translational Science
Hit-to-Lead Studies of Pyrazinylpiperazines against Visceral Leishmaniasis: Pharmacokinetic Profile and In Vivo Efficacy
Biotech
Towards a Survival-Based Cellular Assay for the Selection of Protease Inhibitors in Escherichia coli
Biochimica et Biophysica Acta – Proteins and Proteomics
Role of N-terminal of metacaspase of Candida albicans in calcium binding
Frontiers in Bioinformatics
Beyond Tanimoto: a learned bioactivity similarity index enhances ligand discovery
Revista Argentina de Microbiología
Optimized DNA extraction protocol for Staphylococcus aureus strains utilizing liquid nitrogen
International Journal of Molecular Sciences
Pulmonary Myeloid Cells in Mild Cases of COVID-19 Upregulate the Intracellular Fc Receptor TRIM21
ACS Omega
PAPreC: A Pipeline for Antigenicity Prediction Comparison Methods across Bacteria
The Lancet Regional Health – Americas
Primary health care data-based early warning system for dengue outbreaks: a nationwide case study in Brazil
The Journal of Immunology
Immunoregulatory macrophages induced by mycobacterial nonpolar lipids
Frontiers in Immunology
rBCG-LTAK63 Enhances Protection Against Tuberculosis by Inducing Autophagy and Circadian Gene Regulation
BMC Genomics
Exploring a gene co-expression network throughout the Trypanosoma cruzi life cycle
bioRxiv (Preprint)
Metabolic reshaping drives novel melanin production from tryptophan in a cystic fibrosis Pseudomonas aeruginosa clinical isolate
medRxiv (Preprint)
Microenvironment-driven phenotypic shifts in Staphylococcus aureus from children with cystic fibrosis: a longitudinal cohort study
Microbial Biotechnology
Genetic Dissection of Cyclic di-GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption
Biophysical Reviews
RND/HAE-1 members in the Pseudomonadota phylum: exploring multidrug resistance
Journal of Biological Chemistry
Abstract 1200 Expanding antimicrobial targets and new classes of growth inhibitors with CIMPLE-seq
npj Antimicrobials and Resistance
Innovative perspectives on the discovery of small molecule antibiotics
US Patent Application
Aqueous Hop Extracts and Their Use as Antimicrobial Agents
Frontiers in Pharmacology
Multidrug resistant bacteria: new therapeutic approaches for a challenging problem
Frontiers in Immunology
Clinical isolates of Providencia rettgeri and Providencia Stuartii evades neutrophil-mediated killing
Frontiers in Pharmacology
Effectiveness of infection control measures informed by a modified Blue-Carba test in general wards
Infection, Genetics and Evolution
Plasmid diversity in Klebsiella pneumoniae ST307 co-producing KPC plus NDM recovered during the COVID-19 pandemic
Journal of Global Antimicrobial Resistance
Emerging resistance to novel β-lactam β-lactamase inhibitor combinations in Klebsiella pneumoniae bearing KPC variants
Journal of Global Antimicrobial Resistance
Novel allelic variants of blaOXA-48-like carried on IncN2 and IncC2 plasmids isolated from clinical cases in Argentina
Microbiological Research
Klebsiella pneumoniae ST258 impairs intracellular elastase mobilization and persists within human neutrophils
Parasitology Research
Immunolocalization and 3D modeling of three unique proteins belonging to the costa of Tritrichomonas foetus
Scientific Reports
Statine-based peptidomimetics as SARS-CoV-2 Papain-like protease inhibitors: in Silico and in vitro studies
Scientific Reports
Genomic, socio-environmental, and sequencing capability patterns in the surveillance of SARS-CoV-2 in Latin America and the Caribbean up to 2023
Science of the Total Environment
Antibiotic-resistance genes and metals increase in polluted tropical rivers of the Baia da Ilha Grande, Rio de Janeiro, Brazil
BMC Microbiology
Bacillus velezensis Bac-9, isolated from kefir, possesses antifungal activity and improves resistance of tomato plant against whitefly Bemisia tabaci
Scientific Reports
Comparative genomic analysis of resistance and virulence genes in Staphylococcus epidermidis and their impact on clinical outcome of musculoskeletal infections
Future Virology
New antiviral peptides inhibit in vitro infection of SARS-CoV-2
bioRxiv (Preprint)
Conserved Axonal Transcriptome Dynamics Underlie PGE 2 -Induced Sensitisation and Identify Tnfrsf12a/ Fn14 as a Regulator of Neuronal Excitability in DRG Neurons
ACS Omega
Exploring the Conformational Effects of N- and C-Methylation of N-Acylhydrazones
ACS Omega
Synthesis, Characterization, and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles Coated with Antitumor Molecules
International Journal of Molecular Sciences
A Pharmacologic Approach Against Glioblastoma — A Synergistic Combination of a Quinoxaline-Based and a PI3K/mTOR Dual Inhibitor
Expert Opinion on Therapeutic Patents
Rho kinase inhibitors: a patent review (2017-2023)
ACS Infectious Diseases
Collaborative Synthesis for Neglected Diseases through the Open Synthesis Network: Structure-Activity Relationships of Arylaminopyrazoles as Chagas Disease Treatments
Anti-Cancer Agents in Medicinal Chemistry
State of the Art of IDH Inhibitors: Emerging Questions and Perspectives
Pharmaceuticals
Mechanistic Advances in the Therapeutic Application of Bixin for Lung Inflammation In Vitro and In Vivo
Archiv der Pharmazie
Investigation on LASSBio-1971 and LASSBio-1974 Cellular Cytotoxic Mechanism and Their Comparative DMPK Profile
Pharmaceuticals
Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling
Frontiers in Immunology
The immunomodulatory and antitumor properties of the bacterial metalloprotease Oligopeptidase A are mediated by TLR4/MyD88/TRIF and MAPK signaling pathways
Repeat Amino Acid Sequences in Proteins
Aromatic Clusters in Proteins: Folding, Drug Interactions and Protein-Protein Complexes
4th Molecular Biosystems Conference
Differential composition of the translational machinery of Trypanosoma cruzi during metacyclogenesis and cell cycle
Parasitology Research
Immunolocalization and 3D modeling of three unique proteins belonging to the costa of Tritrichomonas foetus
Frontiers in Pharmacology
Effectiveness of infection control measures informed by a modified Blue-Carba test in reducing rectal carriage of carbapenemase-producing bacteria in general wards
Frontiers in Pharmacology
From genomics to treatment: overcoming pan-drug-resistant Klebsiella pneumoniae in clinical settings
2024
Briefings in Bioinformatics (Vol. 25, No. 6)
Predicting bacterial transcription factor binding sites through machine learning and structural characterization based on DNA duplex stability
2020 - 2023
Frontiers in Microbiology (2023)
The gene regulatory network of Staphylococcus aureus ST239-SCC mec III strain Bmb9393
Bioinformatics Advances (2023)
PPIntegrator: semantic integrative system for protein–protein interaction
Frontiers in Cellular and Infection Microbiology (2022)
Pathway driven target selection in Klebsiella pneumoniae: Insights into carbapenem exposure
Scientific Reports (2021)
Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2
Frontiers in Bioinformatics (2021)
Large-scale protein interactions prediction by multiple evidence analysis associated with an in-silico curation strategy
Clinical Infectious Diseases (2020)
An emerging clone, KPC-2-producing Klebsiella pneumoniae ST16, associated with high mortality rates
2010 - 2019
Frontiers in Microbiology (2019)
Local diversification of methicillin-resistant Staphylococcus aureus ST239 in South America
Scientific Reports (2018)
An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets
Aquatic Toxicology (2018)
Characterization of Laguncularia racemosa transcriptome and molecular response to oil pollution
Memórias do Instituto Oswaldo Cruz (2017)
Complete genome sequence of community-associated MRSA (strain USA400-0051)
Genome Biology and Evolution (2016)
Complete genome sequence of the MRSA isolate HC1335 from ST239 lineage
BMC Microbiology (2012)
AtlasT4SS: a curated database for type IV secretion systems
BMC Genomics (2012)
Genomic basis of broad host range and environmental adaptability of Rhizobium tropici CIAT 899
Frontiers in Microbiology (2016)
Exploratory investigation of Bacteroides fragilis transcriptional response during in vitro exposure to metronidazole
International Journal of Medical Microbiology (2016)
A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in CA-MRSA
Tuberculosis (2016)
A whole genome bioinformatic approach to determine potential latent phase specific targets in Mycobacterium tuberculosis
Antimicrobial Agents and Chemotherapy (2015)
Characterization of BKC-1 class A carbapenemase from Klebsiella pneumoniae clinical isolates in Brazil
BMC Genomics (2014)
Comparative analysis of the complete genome of KPC-2-producing Klebsiella pneumoniae Kp13
Genome Announcements (2013)
Complete genome sequence of a variant of the MRSA ST239 lineage, strain BMB9393
2000 - 2009
Functional & Integrative Genomics (2009)
Novel genes related to nodulation, secretion systems, and surface structures revealed by a genome draft of Rhizobium tropici
Nucleic Acids Research (2008)
The Universal Protein Resource (UniProt)
Soil Biology and Biochemistry (2008)
Genomic panorama of Bradyrhizobium japonicum CPAC 15
Journal of Bacteriology (2005)
Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma
PNAS (2003)
The complete genome sequence of Chromobacterium violaceum reveals remarkable and exploitable bacterial adaptability
1996 - 1999
Applied Soil Ecology (1998)
Persistence of Bradyrhizobium japonicum in arable soils of Argentina
Relatório de Pesquisa (1996)